prostate cancer and breast cancer in the bones usually reappears
So says new study by the University of Michigan. Cancer cells act largely as stem cells in the sense that they reproduce, so the research team developed the hypothesis that prostate cancer cells may move to the niche during metastasis.
As bad neighbors who decide to ruin the neighborhood prostate cancer and breast cancer usually recurs in the bones, according to a new study from the University of Michigan.
now UM researchers believe they know why this happens. The prostate cancer cells specifically target, and eventually conquer the niche of the bone marrow, an area specialized cells hematopoietic stem cells that produce red and white blood, "said Russell Taichman, Professor at the School of Dentistry, UM and author of the study.
Once in that niche cancer cells remain dormant and become active again when, years later, is when tumors recur in the bones. The study implies that occur could be understood how the latency and recurrence.
Taichman and a team of researchers found the bone marrow and found cancer cells and hematopoietic stem cells close to each other and competing for the same site. This finding is significant because it demonstrates the niche of the bone marrow plays a central role in bone metastasis-the spread of cancer in the bone, and gives researchers a new potential target for drugs.
drugs could be developed that prevent return of cancer types, most likely, turn into bone, Taichman said. For example, these drugs could halt or disrupt the way in which the cancerous cells enter the niche or behave in it, or could prevent cancer cells are winners in the competition with stem cells.
Cancer cells act largely as stem cells in the sense that they reproduce, and that's why the UM research group developed the hypothesis that prostate cancer cells may move to the niche during metastasis. One role of the niche is to prevent proliferation of hematopoietic stem cells, which could also be the case for cancer cells, the researchers found.
why cancer recurs? Say a person has a tumor and surgeons removed or subjected to radiation, but the cancer recurs in the bone cell five years later, Taichman said. These cancer cells had been circulating in the body long before it was discovered the cancer, and one of the sites where they hide is in the niche.
"What have you been doing cancer cells during those five years? Now we have a partial answer: they have been waiting on this site whose function is to prevent proliferation and grow things," says Taichman. "Our work explains in part why the current chemotherapies often fail because once cancer cells enter the niche probably cease to proliferate," said Yusuke Shiozawa, author of the study. "The problem is that most medications used to treat cancer only work with proliferating cells.
metastases with most common malignant tumors affecting the skeleton and almost 70 percent of patients with breast and prostate cancer have bone problems. About 15 to 30 percent of patients with lung cancer, colon, stomach, bladder, uterus, rectum, thyroid or kidney disease suffer from bone lesions.
Researchers are not sure about how cancer cells gain in competition with cells mother in the niche. But know that stem cells are displaced because when cancer cells were in the niche scientists also found evidence of blood stem cells in the bloodstream, rather than in the bone marrow which is where they are supposed to be, Taichman said.
"Eventually all the blood system collapse," he said. "For example, the patient eventually becomes anemic, acquired infection and bleeding. I really do not know why people die with prostate cancer. Terminates dying for different types of complications, partly because the bone has been conquered by cancer."
The next step is to determine how tumor cells enter the niche and become dormant, and what exactly do stem cells when they are there. The researchers also want to know whether other types of cancer cells, such as breast cancer, are also the niche.
The study "Prostate Cancer Metastases Hematopoietic Stem Cell Target the Niche to Footholds Established in Marrow" is published online in the Journal of Clinical Investigation.
Co-authors are: Elizabeth Pedersen, Aaron Havens, Younghun Jung, Anjali Mishra, Jeena Joseph, Jin Koo Kim, Anne Ziegler, Michael container, Jingcheng Wang, Junhui Song and Paul Krebsbach, School of Dentistry, UM; Lalit Patel, Chi Ying, Kenneth Robert Loberg and container from the departments of Urology Internal Medicine and School of Medicine, UM.
Published in: rionegro.com.ar
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